Mixing any chemicals can result in unfavorable results. It is always best to ask a trusted pool store associate or call the product’s manufacturer before combining chemicals. Here are a couple of rules to live by: 1) Never pour chemicals together in the same container, 2) Never add water to chemicals, instead add chemicals to water, 3) Never add chemicals to your pool close to the surface at the same location time after time. It’s best to “take a walk” with your chemical applications and never allow them to contact skin or pool surfaces directly. We’ve found over the years that PristineBlue is compatible with most chemicals when added to the pool or spa as previously stated. We ARE compatible with chlorine, bromine, and salt chlorine generators. DEFINITELY DO NOT use the following products with the PristineBlue maintenance system: METAL OUT (products to remove metals, i.e., iron from your water) Call us first. ALGAECIDES (it is unnecessary, and many contain copper which could lead to overdosing) BIGUANIDES (also known by the brands Baquacil* and Soft Swim**) IONIZERS (copper or copper/silver)